https://phys.org/nanotech-news/bio-medicine en-us The latest science news on nanobiology, nano medicine, nanotechnology, nanoscience, and nanotech. New research has demonstrated the potential for the ADDomer platform to produce thermostable vaccines and reagents to tackle viral infections The study led by the University of Bristol and Imophoron, a biopharmaceutical company developing thermostable nanoparticle vaccines using its ADDomer platform, is published in Antibody Therapeutics today (Nov. 29) under the title "In vitro generated antibodies guide thermostable ADDomer nanoparticle design for nasal vaccination and passive immunization against SARS-CoV-2." https://phys.org/news/2023-11-ability-thermostable-nanoparticle-platform-tackle.html Bio & Medicine Wed, 29 Nov 2023 10:48:03 EST news620477281 Nanodiamonds are 2–8 nm carbon nanoparticles, which can be easily functionalized with various chemical groups like carboxylic groups or drugs. Previous research has shown that actively dividing cells are more likely to absorb nanodiamonds and that epithelial cells treated with carboxylic nanodiamonds lose the ability to migrate across cell-permeable cellulose membranes. https://phys.org/news/2023-11-nanodiamonds-block-tumor-metastasis-mice.html Bio & Medicine Wed, 29 Nov 2023 09:47:02 EST news620473621 The COVID-19 pandemic demonstrated the importance of being prepared with drug interventions to contain viral outbreaks that can otherwise have devastating consequences. In preparing for the next pandemic—or Disease X, there is an urgent need for versatile platform technologies that could be repurposed upon short notice to combat infectious outbreaks. https://phys.org/news/2023-11-nano-sized-cell-particles-intervention-tool.html Bio & Medicine Tue, 28 Nov 2023 10:34:04 EST news620390042 Take a pill, or get a shot? Given the choice, most people would likely go for the former. https://phys.org/news/2023-11-oral-delivery-possibility-silica-based-nanocarriers.html Bio & Medicine Mon, 27 Nov 2023 13:10:24 EST news620313019 Researchers at the LKS Faculty of Medicine of the University of Hong Kong (HKUMed), and collaborators from the Zhongshan Ophthalmic Center of Sun Yat-sen University, Guangzhou, have developed a light-activatable prodrug nanomedicine for age-related macular degeneration (AMD) therapy. https://phys.org/news/2023-11-photoactivatable-nanomedicine-treatment-age-related-macular.html Bio & Medicine Mon, 27 Nov 2023 12:43:43 EST news620311421 Richard Feynman famously stated, "Everything that living things do can be understood in terms of the jigglings and wigglings of atoms." This week, Nature Nanotechnology features a study that sheds new light on the evolution of the coronavirus and its variants of concern by analyzing the behavior of atoms in the proteins at the interface between the virus and humans. https://phys.org/news/2023-11-jigglings-wigglings-atoms-reveal-key.html Bio & Medicine Mon, 27 Nov 2023 12:34:04 EST news620310842 In recent years, cell and gene therapies have shown significant promise for treating cancer, cystic fibrosis, diabetes, heart disease, HIV/AIDS and other difficult-to-treat diseases. But the lack of effective ways to deliver biological treatments into the body has posed a major barrier for bringing these new therapies to the market—and, ultimately, to the patients who need them most. https://phys.org/news/2023-11-platform-key-problems-drug-delivery.html Bio & Medicine Mon, 27 Nov 2023 12:32:06 EST news620310721 A Johns Hopkins materials scientist and a team of collaborators have developed a tiny device that may hold promise for restoring mobility to those with lower limb paralysis, a condition affecting approximately 1.4 million Americans. https://phys.org/news/2023-11-tiny-spinal-big-impact-paralysis.html Bio & Medicine Mon, 27 Nov 2023 11:39:03 EST news620307541 Optothermal nanotweezers are an innovative optical design method that has revolutionized classical optical techniques to capture a broad range of nanoparticles. While the optothermal temperature field can be employed for in situ regulation of nanoparticles, challenges remain in identifying their potential for regulating bionanoparticles. https://phys.org/news/2023-11-crispr-powered-optothermal-nanotweezers.html Bio & Medicine Nanophysics Mon, 27 Nov 2023 09:59:01 EST news620301538 The capacity to regulate the biodistribution of therapeutics is a highly desired feature that can limit the side effects of many drugs. In a new study in Scientific Reports, Noah Joseph, and a team of biotechnology and nanoscience scientists in Israel, describe a nanoscale agent developed from a coupled polymer-DNA origami hybrid capable of exhibiting stability in serum and slow diffusion through tissues. https://phys.org/news/2023-11-biodistribution-function-polymer-dna-origami-nanostructures.html Bio & Medicine Fri, 24 Nov 2023 09:50:01 EST news620039050 Seas, oceans, rivers, and other bodies of water on Earth have become increasingly polluted over the past decades, and this is threatening the survival of many aquatic species. This pollution takes a wide range of forms, including the proliferation of so-called micro and nano plastics. https://phys.org/news/2023-11-biohybrid-microrobots-micro-nano-plastics-aquatic.html Bio & Medicine Nanomaterials Fri, 24 Nov 2023 09:10:01 EST news620039155 Biological computing machines, such as micro and nano-implants that can collect important information inside the human body, are transforming medicine. Yet, networking them for communication has proven challenging. Now, a global team, including EPFL researchers, has developed a protocol that enables a molecular network with multiple transmitters. https://phys.org/news/2023-11-networking-nano-biosensors-wireless-communication-blood.html Bio & Medicine Wed, 22 Nov 2023 12:42:01 EST news619879318 Optothermal nanotweezers, an innovative optical manipulation technique over the past decade, have revolutionized classical optical manipulation by efficiently capturing a broader spectrum of nanoparticles. While this technique has been primarily used for in-situ manipulation of nanoparticles, its potential for identifying bio-nanoparticles remains largely unexplored. https://phys.org/news/2023-11-cront-empowering-optical-tweezers-biometric.html Bio & Medicine Nanophysics Wed, 22 Nov 2023 11:18:32 EST news619874309 By giving living cells a "nano-poke" and monitoring the resulting changes in the intracellular environment, researchers have gotten their first glimpse of how whole cells respond to external mechanical pressure. https://phys.org/news/2023-11-nano-sized-probes-reveal-cellular-pressure.html Bio & Medicine Tue, 21 Nov 2023 14:03:18 EST news619797795 A research team led by Professor Sei Kwang Hahn and Dr. Tae Yeon Kim from the Department of Materials Science and Engineering at Pohang University of Science and Technology (POSTECH) used gold nanowires to develop an integrated wearable sensor device that effectively measures and processes two bio-signals simultaneously. Their research findings were featured in Advanced Materials. https://phys.org/news/2023-11-team-gold-nanowires-wearable-sensor.html Bio & Medicine Nanomaterials Mon, 20 Nov 2023 12:45:01 EST news619706698 Proteins that form clumps occur in many difficult-to-treat diseases, such as ALS, Alzheimer's, and Parkinson's. The mechanisms behind how the proteins interact with each other are difficult to study, but now researchers at Chalmers University of Technology, Sweden, have discovered a new method for capturing many proteins in nano-sized traps. Inside the traps, the proteins can be studied in a way that has not been possible before. https://phys.org/news/2023-11-tiny-protein-interactions-knowledge-difficult-to-treat.html Bio & Medicine Mon, 20 Nov 2023 11:26:03 EST news619701961 Venous malformations—tissues made up largely of abnormally shaped veins—are often difficult to treat, especially when located in sensitive areas like the eyes, face, and genitourinary organs. In the worst cases, the lesions are disfiguring and can crush or obstruct surrounding tissues, cause bleeding and clotting, interfere with breathing or vision, or impair circulation. https://phys.org/news/2023-11-gold-nanoparticles-venous-malformations.html Bio & Medicine Mon, 20 Nov 2023 10:27:04 EST news619698421 Researchers at the Institute of Physical Chemistry of the Polish Academy of Sciences (IPC PAS) have demonstrated that green tea–silver nanoparticles as a powerful tool against pathogens such as bacteria and yeast. Their work is published in Nanoscale Advances. https://phys.org/news/2023-11-antimicrobial-silver-nanoparticles-pathogens-tea.html Bio & Medicine Nanomaterials Fri, 17 Nov 2023 12:47:19 EST news619447631 Sentinel lymph node (SLN) is the first lymph node draining from a tumor, and sentinel lymph node biopsy (SLNB) for breast cancer is the standard procedure for clinically node-negative (cN0) early-stage breast cancer. Currently, the commonly used tracers in clinical practice can only trace SLNs without evaluating their metastatic status. https://phys.org/news/2023-11-nanoprobe-vivo-real-time-sentinel-lymph.html Bio & Medicine Thu, 16 Nov 2023 12:33:03 EST news619360381 As the aging population around the world grows, metabolic diseases like osteoporosis are becoming more prevalent and placing a greater burden on health care systems. Rising to this challenge, a research team led by Prof. Wong Ka-hing, Director of the Research Institute for Future Food and Professor of the Department of Food Science and Nutrition at The Hong Kong Polytechnic University (PolyU), has developed novel selenium nanoparticles (Cs4-SeNPs) for managing postmenopausal osteoporosis. https://phys.org/news/2023-11-selenium-nanoparticles-postmenopausal-osteoporosis.html Bio & Medicine Wed, 15 Nov 2023 10:53:55 EST news619268032 Pancreatic cancer is one of the deadliest types of cancers in humans. It is the fourth leading cause of cancer-related deaths in the western world. The early stages of the disease often progress without symptoms, so diagnosis is usually very late. Another problem is advanced tumors—and their metastases—can no longer be completely removed. Chemotherapies, in turn, attack not only the tumor cells but also healthy cells throughout the body. https://phys.org/news/2023-11-nanoparticle-treatment-approach-optimized-pancreatic.html Bio & Medicine Wed, 15 Nov 2023 10:52:50 EST news619267958 Protein cages found within microbes help its contents weather the harsh intracellular environment—an observation that has many bioengineering applications. Tokyo Tech researchers have recently developed an innovative bioengineering approach that uses genetically modified bacteria to incorporate protein cages around protein crystals. This in-cell biosynthesis method efficiently produces highly customized protein complexes, which could find applications as advanced solid catalysts and functionalized nanomaterials. https://phys.org/news/2023-11-bacteria-biosynthesize-intricate-protein-complexes.html Bio & Medicine Nanomaterials Wed, 15 Nov 2023 09:39:44 EST news619263581 All cells secrete nanoscale extracellular vesicles naturally as lipid-bilayer delimited particles. Therefore they are valid biomarkers to identify a variety of diseases. https://phys.org/news/2023-11-rapid-purification-characterization-circulating-small.html Bio & Medicine Wed, 15 Nov 2023 09:35:49 EST news619263346 Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide. For most intermediate-advanced HCC patients, transarterial embolization (TAE) therapy is the mainstream treatment by utilizing embolic agents to block the tumor blood supply to induce ischemic necrosis attributing to its minimal invasiveness. https://phys.org/news/2023-11-nano-caco-stabilized-ferroptosis-inducing-lipiodol-based.html Bio & Medicine Tue, 14 Nov 2023 11:12:03 EST news619182721 Autoimmune disorders are among the most prevalent chronic diseases across the globe. Emerging treatments for autoimmune disorders focus on "adoptive cell therapies," or those using cells from a patient's own body to achieve immunosuppression. These therapeutic cells are recognized by the patient's body as "self," therefore limiting side effects, and are specifically engineered to localize the intended therapeutic effect. https://phys.org/news/2023-11-lipid-nanoparticles-mrna-cells-autoimmune.html Bio & Medicine Tue, 14 Nov 2023 10:37:53 EST news619180670 Researchers in Purdue University's College of Engineering have invented and are developing noninvasive medical devices to make the monitoring and treatment of certain physiological and psychological conditions timelier and more precise. https://phys.org/news/2023-11-sensors-uric-acid-noninvasive-methods.html Bio & Medicine Nanomaterials Wed, 08 Nov 2023 11:47:03 EST news618666421 By rapidly reversing the effects of an opioid overdose, naloxone saves lives―if it's available at the right time. To eliminate this element of chance, researchers are exploring ways to have the medication available in the body before it's needed. https://phys.org/news/2023-11-team-nanoparticles-naloxone-triggered-blue.html Bio & Medicine Wed, 08 Nov 2023 10:04:03 EST news618660242 A research team in Japan, led by Nagoya University's Akira Yokoi, has developed an innovative technique using cellulose nanofiber (CNF) sheets derived from wood cellulose to capture extracellular vesicles (EVs) from fluid samples and even organs during surgery. https://phys.org/news/2023-11-extracellular-vesicles-captured-sustainable-wood.html Bio & Medicine Wed, 08 Nov 2023 05:00:02 EST news618589506 Vaterite is one of the three forms of calcium carbonate, along with calcite and aragonite. Nanosized vaterite is valuable for various applications, such as drug delivery, cosmetics, and bone defect filling, owing to its biocompatibility, high porosity, solubility, and large specific surface area. https://phys.org/news/2023-11-organic-solvent-free-method-nanosized-vaterite.html Bio & Medicine Nanomaterials Tue, 07 Nov 2023 15:27:03 EST news618593222 Recurring influenza epidemics, such as the one during World War I, the Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in the 2010s, and the COVID-19 pandemic in recent years have made it evident that contagious viral respiratory diseases often make an appearance in the timeline of human history. https://phys.org/news/2023-11-metal-enhanced-fluorescence-probes-influenza-virus.html Bio & Medicine Nanomaterials Tue, 07 Nov 2023 11:31:04 EST news618579061